Nervonic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

神经酸是一种长链不饱和脂肪酸，富含鞘磷脂。它由胆碱、鞘氨醇、磷酸和脂肪酸组成。

Nervonic acid is a long chain unsaturated fatty acid that is enriched in sphingomyelin. It consists of choline sphingosine phosphoric acid and fatty acid. Nervonic acid may enhance the brain functions and prevent demyelination (Chemical Land21). Research shows that there is negative relationship between nervonic acid and obesity-related risk factors. Demyelination in adrenoleukodystrophy (ALD) is associated with an accumulation of very long chain saturated fatty acids stemming from a genetic defect in the peroxisomal beta oxidation system responsible for the chain shortening of these fatty acids. Sphingolipids from post mortem ALD brain have decreased levels of nervonic acid 24:1(n-9) and increased levels of stearic acid 18:0.

Cell Viability Assay Cell Line:PC-12 Concentration:0.001, 0.01, 0.1, 1. 10 μM Incubation Time:48 h Result:Increased cell viability pretreated with a very low concentration.Western Blot Analysis Cell Line:RAW264.7 Concentration:12.5, 25, 50 μM Incubation Time:24 h Result:Decreased the expression of TLR4, JNK, P38 and NF-κB.

Animal Model:MPTP-induced PD mice modelDosage:20, 40, 60 mg/kg Administration:i.g.Result:Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response.Animal Model:DSS-induced colitis mice modelDosage:5, 50, 100mg/kg Administration:i.g.Result:Improved the symptoms of diarrhea, weight loss and fecal occidental blood.Reduced the levels of COX-2 and iNOS.

cis-15-Tetracosenoic acid | Selacholeic acid

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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506-37-6

366.62

C24H46O2

>98% (HPLC)

DMSO:10 mM;Water:1mg/mL

CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years